--- Query Results --- | |||||||
| Organization: | Alberta Precision Laboratories | ||||||
| Message Alert: | PLEASE NOTE: This Test Directory is in an interim state and due to changes pertaining to the DynaLIFE transition, performing site for routing has not been updated. Please refer to Laboratory Information System for appropriate routing. | ||||||
| Test Name/Synonym: | Beta-Glucosidase, T-cell (Synonym: Beta-glucocerebrosidase, Gaucher, Glucosylceramidase, Lysosomal Enzymes Panel) | ||||||
| Clinical Indications: | For the investigation of Gaucher Disease (a.k.a., acid beta-glucosidase deficiency, glucocerebrosidase deficiency) - a lysosomal storage disorder. | ||||||
| Test Includes: | Beta-Glucosidase activity | ||||||
| Ordering Alert: | For those sites that routinely refer tests to Edmonton zone labs, refer to Beta-Glucosidase, Leukocyte Connect Care Users: Order Lysosomal Enzymes (LAB4043), then select the enzyme(s) to be tested. If ordering through Requisition Entry, order the individual enzyme. This test is considered specialty testing; this test will be cancelled if sufficient clinical justification is not provided. Requests for testing should be supported by a high index of clinical suspicion specific to the disorder in question. | ||||||
| Shipping and Handling Alert: | Specimen must be received by a specific time. See Transportation for details. | ||||||
| LABID (Connect Care): | LAB4720A | ||||||
| Test Code: |
| ||||||
| Specimen Type: | Blood | ||||||
| Primary Container: | Green Top - Sodium Heparin (no gel) | ||||||
| Alternate Containers: | Green Top - Lithium Heparin (no gel) | ||||||
| Minimum Collection Volume: | 3.0 mL | ||||||
| Specimen Collection Requirements: | Collect one Sodium Heparin (or alternate) tube.
| ||||||
| Test Resources: | Submit request using the applicable requisition or Connect Care online order entry:
| ||||||
| Stability and Storage: | Room temperature | ||||||
| Transportation: | Transport whole blood at room temperature.
All specimens MUST arrive in lab by:
| ||||||
| Method: | Fluorometric | ||||||
| Method and Interpretation of Results: | Beta-Glucosidase activity is measured fluorometrically using a 4-methylumbelliferyl-linked substrate.
This procedure involves the establishment of an IL-2 stimulated T-lymphocyte culture and storage of cell pellets for the purpose of lysosomal enzyme testing. | ||||||
| Routine Turn Around Time: | 45 days | ||||||
| Testing Schedule: | Monthly | ||||||
| Reference Interval: |
| ||||||
| Testing Area: | Biochemical Genetics | ||||||
| Performing Site: | Alberta Children’s Hospital | ||||||
| Additional Test Information: | For priority turn-around contact Biochemical Genetics South Laboratory. | ||||||
| Contact Comments: | Biochemical Genetics South 403-955-7379 | ||||||
| Last Updated On: | Monday, August 29, 2022 | ||||||
| Date of Last Review: | Aug 1 2022 12:00AM | ||||||
