Alberta Precision Laboratories

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Organization:

Alberta Precision Laboratories

Message Alert:

PLEASE NOTE: This Test Directory is in an interim state and due to changes pertaining to the DynaLIFE transition, performing site for routing has not been updated. Please refer to Laboratory Information System for appropriate routing.

Test Name/Synonym:

Doxepin and Metabolite Level (Synonym: Adapine, Aponal, Nordoxepin, Sinequan)

Ordering Alert:

Record time of last dose on requisition or in electronic ordering system.

Collection Alert:

Collect within 1 hour before next dose or greater than 12 hours after last dose.

LABID (Connect Care):

LAB146

Test Code:

CALGARY, CENTRAL, EDMONTON ZONES	DOX
NORTH ZONE	DOXNORDT
SOUTH ZONE	DOXNORD

Specimen Type:

Blood

Primary Container:

RED

Minimum Collection Volume:

0.5 mL serum

Test Resources:

General Laboratory Requisition – 21302 write test name under “Additional Tests”

Half-life and Time to Steady State

Calgary Zone: Microcollection Minimum Whole Blood Volumes

Stability and Storage:

Refrigerated – 1 week

Processing:

Freeze aliquot if specimen will not be received at performing lab within 1 week.
Freeze upon receipt at performing lab.

Transportation:

Calgary Zone:

Calgary, Airdrie, Cochrane, and Chestermere collection sites: transport at room temperature.
Other collection sites: transport frozen.
Diagnostic Scientific Centre: Store frozen after receipt.

Other Zones: transport serum frozen.

Method:

Liquid Chromatography – Mass Spectrometry/Mass Spectrometry

Testing Schedule:

Batched - test performed within 2 weeks of receipt

Reference Interval:

Target Range: 400 - 920 nmol/L (Total doxepin and nordoxepin)

Critical Value:

Greater than 2000 nmol/L (Total doxepin and nordoxepin)

Testing Area:

TDM/Toxicology

Performing Site:

Edmonton: University of Alberta Hospital

Additional Test Information:

Steady state: 6-11 days

Last Updated On:

Wednesday, July 21, 2021