Alberta Precision Laboratories

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Organization:

Alberta Precision Laboratories

Test Name/Synonym:

Hereditary Thrombophilia Investigations (Synonym: Antiphospholipid Syndrome Investigation, Antithrombin, clotting, Coagulopathy, Coagulation, embolus, embolism, Factor V Leiden, Factors, Protein S, Protein C, Prothrombin G2021A Variant, Thrombosis Investigations, thrombus)

Collection Alert:

All Hospitals (Inpatients and Outpatient collection labs) can collect. For community Patient Service Centres (PSC), testing can ONLY be collected at the PSCs listed below.

Shipping and Handling Alert:

Specimens are time sensitive.

LABID (Connect Care):

LAB4347

Specimen Type:

Blood

Primary Container:

LT BLUE CITRATE if Protein C, Protein S or Antithrombin are ordered
AND
LAVENDER EDTA if Factor V Leiden or Prothrombin G20210A Variant are ordered

Minimum Collection Volume:

For testing sent to Calgary:
Five 2.7 mL LT BLUE CITRATE tubes, allow the vacuum tube to completely fill, minimum fill is to frosted line on tube and one LAVENDER EDTA If Factor V Leiden or Prothrombin G20210A Variant are ordered.

For testing sent to Edmonton:
One 2.7mL LT BLUE CITRATE tube per test and one LAVENDER EDTA IF Factor V Leiden or Prothrombin G20210A Variant are ordered.

For pediatric and neonate testing contact Special Coagulation Laboratory. If unable to contact, draw volume according to weight restriction guidelines.

Specimen Collection Requirements:

Light Blue Citrate: It is important to fill tube to maximum draw.
Mix well immediately after collection by inverting tube 3 to 4 times. If venous access is not available, sample can be drawn from a line but 6x the volume of the line or 5 mL (whichever is less) must be removed prior to collection.
When using a winged blood collection set (butterfly needle), a discard tube must be used to remove the air in the tubing, if only a citrate tube is drawn or is the first tube drawn.

All Hospitals (Inpatients and Outpatient collection labs) can collect. For community Patient Service Centres (PSC), testing can ONLY be collected at the PSCs listed below:
Edmonton Zone:	Meadowlark Patient Service Centre Northgate Patient Service Centre Heritage Patient Service Centre Tawa Patient Service Centre Windermere Patient Service Centre Leduc Patient Service Centre Athabasca Place (Sherwood Park) Patient Service Centre
Central Zone:	Camrose Patient Service Centre Red Deer Downtown Patient Service Centre Red Deer Bower Plaza Patient Service Centre Lloydminster Patient Service Centre
North Zone:	Franklin (Fort McMurray) Patient Service Centre Grande Prairie Patient Service Centre
Calgary Zone:	All Calgary Zone Patient Service Centres
South Zone:	Medicine Hat Patient Service Centre Lethbridge Centre Village Patient Service Centre Lethbridge Highlands Patient Service Centre Brooks Patient Service Centre
Mobile	Test cannot be collected by Mobile Collection Service (MCS).

Test Resources:

Special Coagulation Testing Requisition Hereditary Thrombophilia Investigations

Stability and Storage:

LT BLUE CITRATE: Room temperature – 3.5 hours
LAVENDER EDTA: Refrigerated - up to 3 days

Processing:

For LAVENDER EDTA:

Room temperature, unspun

For LT BLUE CITRATE specimens:

For testing sent to Calgary:	For testing sent to Edmonton:
For specimens that will be received beyond stability: Centrifuge to obtain platelet poor plasma (platelet count <10 x 10⁹/L) Aliquot plasma as per Special Coagulation Aliquoting sent to Calgary PX06-01.600 Specimens MUST be accompanied by a copy of the original requisition. Send the original requisition for optical scanning.	Centrifuge to obtain platelet poor plasma (platelet count <10 x 10⁹/L) Aliquot each test as per Special Coagulation Aliquoting sent to Edmonton PX06-01.610

Platelet poor plasma must be prepared in accordance with the College of Physician and Surgeons of Alberta (CPSA) Laboratory Standard H.4.3.4. This must include procedures for regular verification that centrifuge(s) reliably produce plasma containing <10 x 10⁹/L residual platelets. Please contact Special Coagulation in Calgary 403-770-3598 (ext 3) or in Edmonton 780-407-8487 for detailed instructions.

Transportation:

Room temperature – uncentrifuged
Frozen (dry ice if available) - Specimens must maintain frozen state for entire duration of transport.

Testing Schedule:

Batched

For stat testing in Calgary: Contact Special Coagulation Laboratory. After hours contact the Hematopathologist on call.

For stat testing in Edmonton: MUST contact the Hematopathologist or Clinical Biochemist on call.

Reference Interval:

See Laboratory Report

Testing Area:

Special Coagulation

Performing Site:

Calgary Zone	Diagnostic and Scientific Centre
Edmonton Zone	University of Alberta Hospital

Contact Comments:

1-877-868-6848

Last Updated On:

Wednesday, April 9, 2025