Alberta Precision Laboratories

--- Query Results ---

Organization:

Alberta Precision Laboratories

Message Alert:

PLEASE NOTE: This Test Directory is in an interim state and due to changes pertaining to the DynaLIFE transition, performing site for routing has not been updated. Please refer to Laboratory Information System for appropriate routing.

Test Name/Synonym:

Methadone Level (Synonym: dolophine, metadol, methadose)

Clinical Indications:

Level monitoring is done in pain management and addiction treatment situations:

To verify compliance
To determine elimination half-life and appropriate dosing regimens, particularly in patients on high doses with inadequate clinical response
To prevent toxicity (pre-dose levels less than 1000 ug/L)

Ordering Alert:

Record time of last dose on requisition or in electronic ordering system.

Collection Alert:

Collect within 1 hour before next dose or greater than 12 hours after last dose. Other specimens may be collected before or after the same dose if specifically requested.

Best practice is to not draw from an intravenous line through which the drug has been administered as it can produce erroneous results and impact patient care. If best practice is not possible, prior consultation with the most responsible health practitioner is required.

LABID (Connect Care):

LAB1054

Test Code:

CALGARY ZONE	METHA
CENTRAL ZONE	MISC
EDMONTON ZONE	LAB1054
NORTH ZONE	ASPEN: MISC PEACE: METHA
SOUTH ZONE	MISC

Primary Container:

Red

Minimum Collection Volume:

1.0 mL serum

Processing:

Centrifuge and aliquot. Freeze serum if it will not be received at performing lab within 1 week.
Freeze upon receipt at performing lab.

Method:

Liquid Chromatography – Mass Spectrometry/Mass Spectrometry

Method and Interpretation of Results:

Results to be interpreted by physician. A minimum serum concentration of 400 µg/L has been proposed for addiction treatment purposes. A target concentration for pain management patients has not been defined.

Testing Schedule:

Batched – performed within 2 weeks of receipt

Critical Value:

Greater than 999 µg/L

Testing Area:

TDM/Toxicology

Performing Site:

Edmonton: University of Alberta Hospital

Additional Test Information:

Steady state 4-12 days

Last Updated On:

Monday, June 27, 2022