--- Query Results --- | ||||||||||
| Organization: | Alberta Precision Laboratories | |||||||||
| Message Alert: | PLEASE NOTE: This Test Directory is in an interim state and due to changes pertaining to the DynaLIFE transition, performing site for routing has not been updated. Please refer to Laboratory Information System for appropriate routing. | |||||||||
| Test Name/Synonym: | Homocysteine, Total, Urine, Random (Synonyms: Homocysteine, Reduced) | |||||||||
| Clinical Indications: | Total homocysteine can be elevated in the following enzyme deficiencies: Disorders Detectable by Elevated Plasma/Urine Total Homocysteine
This test is not recommended for the investigation of nutritional vitamin B12 deficiency, as total homocysteine is not a sensitive marker for this purpose, nor for assessing carrier status of the common methylene tetrahydrofolate reductase (MTHFR) polymorphisms. | |||||||||
| Ordering Alert: | This test is considered specialty testing; this test will be cancelled if sufficient clinical justification is not provided. | |||||||||
| LABID (Connect Care): | LAB4023A | |||||||||
| Test Code: |
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| Specimen Type: | Urine | |||||||||
| Primary Container: | Sterile container | |||||||||
| Alternate Containers: | Non sterile container | |||||||||
| Minimum Collection Volume: | 1.0 mL | |||||||||
| Specimen Collection Requirements: | First morning void is preferred. Collect a 5.0 to 10.0 mL random urine specimen. | |||||||||
| Test Resources: | Submit request using the applicable requisition or Connect Care online order entry:
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| Stability and Storage: | Frozen | |||||||||
| Processing: | This test requires creatinine determination for result reporting. For sites using EPIC, a separate aliquot should be removed at the time of initial specimen receipt and sent to the EPIC-designated lab for creatinine testing.
One aliquot with primary container, or two separate aliquots, can be submitted. Write “urine” on all secondary aliquot tubes. Freeze container and/or tubes. | |||||||||
| Transportation: | Transport frozen specimens on dry ice. Samples must not thaw during transport. | |||||||||
| Method: | LC-MS/MS | |||||||||
| Method and Interpretation of Results: | Total homocysteine is detected following reduction using liquid chromatography, electrospray-ionization tandem mass spectrometry (LC-MS/MS) with a deuterium-labelled internal standard. | |||||||||
| Routine Turn Around Time: | 30 days | |||||||||
| Testing Schedule: | Monthly | |||||||||
| Reference Interval: |
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| Testing Area: | Biochemical Genetics | |||||||||
| Performing Site: | Alberta Children’s Hospital | |||||||||
| Additional Test Information: | For priority turn-around contact Biochemical Genetics South Laboratory. | |||||||||
| Contact Comments: | Biochemical Genetics 403-955-7379 | |||||||||
| Last Updated On: | Tuesday, November 22, 2022 | |||||||||
| Date of Last Review: | Aug 1 2022 12:00AM | |||||||||
