Alberta Precision Laboratories

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Organization:

Alberta Precision Laboratories

Message Alert:

PLEASE NOTE: This Test Directory is in an interim state and due to changes pertaining to the DynaLIFE transition, performing site for routing has not been updated. Please refer to Laboratory Information System for appropriate routing.

Test Name/Synonym:

Cystinuria / Homocystinuria Screen, Urine, Random (Synonyms: Sodium Cyanide Nitroprusside Test, Cystine Screen)

Clinical Indications:

This screen is a simple, rapid and sensitive method for the initial investigation of disorders resulting in increased excretion of thiol-containing metabolites (i.e., homocystinuria and cystinuria).

This test should not be used to monitor known homocystinuria or cystinuria patients on treatment as this is a qualitative test; refer to Cystinuria Monitoring, Urine, Random.

LABID (Connect Care):

LAB387

Test Code:

CALGARY ZONE	BGLNON; IN BGL NON-BLOOD TEST NAME FIELD ENTER CYS SCRN
CENTRAL ZONE	CYSSCUR
EDMONTON ZONE	UCYST
NORTH ZONE	CYSSCUR
OTHER ZONES	NOT SPECIFIED

Specimen Type:

Urine

Primary Container:

Sterile Container

Alternate Containers:

Non-sterile container

Minimum Collection Volume:

1.0 mL

Specimen Collection Requirements:

First morning void is preferred.
Collect a 5.0 to 10.0 mL random urine specimen.

Test Resources:

Submit request using the applicable requisition or Connect Care online order entry:

Biochemical Genetics Laboratory Requisition

Please ensure all required information, including patient's clinical history/indication, is provided on the requisition.

Stability and Storage:

Frozen

Processing:

Specimen can be submitted in primary container or aliquot tube.
If specimen is transferred to secondary aliquot tube or container, write "urine" on label.
Freeze specimen.

Transportation:

Transport frozen specimens on dry ice.
Samples must not thaw during transport.

Method:

Colorimetric

Method and Interpretation of Results:

Increased urinary homocystine or cystine excretion is detected colorimetrically with the addition of sodium cyanide and sodium nitroprusside. Positive and negative controls are run with patient samples.

A positive nitroprusside test suggesting the presence of either increased urine homocystine or cystine will result in reflex testing on this sample, volume permitting. Reflex testing consists of:

Routine Turn Around Time:

10 days

Testing Schedule:

Weekly

Reference Interval:

Interpretation provided on report.

Testing Area:

Biochemical Genetics

Performing Site:

University of Alberta Hospital or Alberta Children’s Hospital

Additional Test Information:

For priority turn-around contact the Biochemical Genetics Laboratoryies.

Contact Comments:

Biochemical Genetics North	Biochemical Genetics South
780-407-8820	403-955-7379

Last Updated On:

Tuesday, November 22, 2022

Date of Last Review:

Aug 1 2022 12:00AM