--- Query Results --- | |||||
| Organization: | Alberta Precision Laboratories | ||||
| Message Alert: | PLEASE NOTE: This Test Directory is in an interim state and due to changes pertaining to the DynaLIFE transition, performing site for routing has not been updated. Please refer to Laboratory Information System for appropriate routing. | ||||
| Test Name/Synonym: | Mucopolysaccharide (Glycosaminoglycan) Screen (Synonyms: GAG, MPS, DMMB, Dimethylmethylene Blue) | ||||
| Clinical Indications: | This screen is a simple and rapid method for the initial investigation for mucopolysaccharidoses (a.k.a., disorders of glycosaminoglycan catabolism). | ||||
| Ordering Alert: | This test should not be used to monitor known mucopolysaccharidosis patients on treatment. For monitoring known patients, please order Quantitative Total GAGs (Monitoring) | ||||
| LABID (Connect Care): | LAB4020 | ||||
| Specimen Type: | Urine | ||||
| Primary Container: | Sterile container | ||||
| Alternate Containers: | Non sterile container | ||||
| Minimum Collection Volume: | 4.0 mL | ||||
| Specimen Collection Requirements: | First morning void is preferred. Collect a 5.0 to 10.0 mL random urine specimen. | ||||
| Test Resources: | Submit request using the applicable requisition or Connect Care online order entry:
| ||||
| Stability and Storage: | Frozen | ||||
| Processing: | Specimen can be submitted in primary container or aliquot tube. If specimen is transferred to secondary aliquot tube or container, write "urine" on label. Freeze specimen. | ||||
| Transportation: | Transport frozen specimens on dry ice. Samples must not thaw during transport. | ||||
| Method: | Spectrophotometric | ||||
| Method and Interpretation of Results: | The dimethylmethylene blue (DMMB) dye forms a complex with sulfated GAGs present in urine, which can then be measured spectrophotometrically at 520nm.
Abnormal screen results will be followed up with MPS Investigation, which includes Uronic Acids quantitation and Glycosaminoglycan Electrophoresis, Qualitative. | ||||
| Routine Turn Around Time: | 10 days | ||||
| Testing Schedule: | Weekly | ||||
| Testing Area: | Biochemical Genetics | ||||
| Performing Site: | University of Alberta Hospital or Alberta Children’s Hospital | ||||
| Additional Test Information: | For priority turn-around contact Biochemical Genetics Laboratory. | ||||
| Contact Comments: |
| ||||
| Last Updated On: | Monday, December 4, 2023 | ||||
| Date of Last Review: | Aug 1 2022 12:00AM | ||||
