--- Query Results --- | |||||||||
| Organization: | Alberta Precision Laboratories | ||||||||
| Test Name/Synonym: | Amiodarone and Metabolite Level (Synonym: Cordarone, Desethylamiodarone) | ||||||||
| Ordering Alert: |
Record time of last dose on requisition or in electronic ordering system. | ||||||||
| Collection Alert: | Collect within 1 hour before next dose. Collect dedicated RED top tube. Do not share serum with other tests. Best practice is to not draw from an intravenous line through which the drug has been administered as it can produce erroneous results and impact patient care. If best practice is not possible, prior consultation with the most responsible health practitioner is required. | ||||||||
| LABID (Connect Care): | LAB567 | ||||||||
| Specimen Type: | Blood | ||||||||
| Primary Container: | RED | ||||||||
| Minimum Collection Volume: | 2.0 mL serum | ||||||||
| Test Resources: |
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| Processing: | Centrifuge and aliquot serum. All collection sites other than Calgary, Airdrie, Cochrane, Chestermere, Okotoks and Strathmore: freeze serum immediately. | ||||||||
| Transportation: |
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| Testing Schedule: | Weekly | ||||||||
| Reference Interval: |
Desirable Amiodarone target range in patients treated for atrial fibrillation is between 1.1-2.2 µmol/L. Patients with normal metabolism have desethylamiodarone concentrations +/- 20% of the parent drug. Toxic Levels: The frequency of adverse effects is related to dosage and duration of therapy. | ||||||||
| Critical Value: | Greater than 5.4 µmol/L (amiodarone) | ||||||||
| Testing Area: | TDM/Toxicology | ||||||||
| Performing Site: | Calgary: Diagnostic and Scientific Centre | ||||||||
| Additional Test Information: | Steady State: Very long. A minimum of at least 4 weeks is desirable between dosage changes for checking a level. | ||||||||
| Last Updated On: | Monday, March 17, 2025 | ||||||||
