Alberta Precision Laboratories

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Organization:

Alberta Precision Laboratories

Message Alert:

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Test Name/Synonym:

Cystinuria / Homocystinuria Screen, Urine, 24 Hour (Synonyms: Sodium Cyanide Nitroprusside Test, Cystine Screen)

Clinical Indications:

This screen is a simple, rapid and sensitive method for the initial investigation of disorders resulting in increased excretion of thiol-containing metabolites (i.e., homocystinuria and cystinuria).

This test should not be used to monitor known homocystinuria or cystinuria patients on treatment as this is a qualitative test; refer to Cystinuria Monitoring, Urine, 24 Hour.

This test is also available on random urines, refer to Cystinuria / Homocystinuria Screen, Urine, Random

LABID (Connect Care):

LAB3871

Test Code:

CALGARY ZONE	BGLNON; IN BGL NON-BLOOD TEST NAME FIELD ENTER CYS SCRN 24
OTHER ZONES	NOT SPECIFIED

Specimen Type:

Urine

Primary Container:

24 hour urine, plain bottle (NO ADDITIVE)

Minimum Collection Volume:

1 mL of the 24 hour urine collection

Specimen Collection Requirements:

Urine specimen MUST be kept FROZEN during entire collection and transport process.

Refer to 24 Hour Urine General Collection - Patient Instructions for detailed instructions. Instruct patient to ensure the 24 hour urine collection container is placed into freezer immediately after each void throughout the 24 hour collection period.

Test Resources:

Submit request using the applicable requisition or Connect Care online order entry:

Biochemical Genetics Laboratory Requisition

Please ensure all required information, including patient's clinical history/indication, is provided on the requisition.

Stability and Storage:

Frozen

Processing:

1. Thaw 24hr urine specimen.
2. Measure total volume (TVOL).
3. Connect Care users, enter TVOL in Connect Care. All other users, write the TVOL amount on the requisition.
4. Aliquot minimum 1 mL of urine.
5. Write “TVOL #” on the aliquot label.
6. Freeze aliquot.

Transportation:

Transport frozen specimens on dry ice.
Samples must not thaw during transport.

Method:

Colorimetric

Method and Interpretation of Results:

Increased urinary homocystine or cystine excretion is detected colorimetrically with the addition of sodium cyanide and sodium nitroprusside. Positive and negative controls are run with patient samples.

A positive nitroprusside test suggesting the presence of either increased urine homocystine or cystine will result in reflex testing on this sample, volume permitting. Reflex testing consists of:

Routine Turn Around Time:

10 days

Testing Schedule:

Weekly

Reference Interval:

Interpretation provided on report.

Testing Area:

Biochemical Genetics

Performing Site:

University of Alberta Hospital or Alberta Children’s Hospital

Additional Test Information:

For priority turn-around contact the Biochemical Genetics Laboratory.

Contact Comments:

Biochemical Genetics North	Biochemical Genetics South
780-407-8820	403-955-7379

Last Updated On:

Wednesday, November 23, 2022