--- Query Results --- | |||
| Organization: | Alberta Precision Laboratories | ||
| Message Alert: | PLEASE NOTE: This Test Directory is in an interim state and due to changes pertaining to the DynaLIFE transition, performing site for routing has not been updated. Please refer to Laboratory Information System for appropriate routing. | ||
| Test Name/Synonym: | Methionine, Dried Blood Spot | ||
| Clinical Indications: | Blood spot methionine quantitation is supplemental to newborn screening and is intended for classical homocystinuria screening in asymptomatic infants. | ||
| Ordering Alert: | This test is intended for homocystinuria screening in asymptomatic infants. As a screening test, both false positive and negative results are possible. Follow up diagnostic testing is required for all infants with a positive result or infants with a clinical suspicion for homocystinuria. | ||
| Shipping and Handling Alert: | Ensure the blood spot is dry before closing the protective flap. | ||
| LABID (Connect Care): | LAB7001 | ||
| Test Code: | 1442 | ||
| Specimen Type: | Dried Blood Spot | ||
| Primary Container: | Newborn Metabolic Screening Blood Spot Requisition (card) | ||
| Minimum Collection Volume: | 2 full blood spots | ||
| Specimen Collection Requirements: | Ensure that expiry date of Newborn Metabolic Screening Blood Spot Requisition (card) has not been exceeded before proceeding with collection. Use a heel poke if patient is less than one year old or a finger poke if older. Collect two saturated blood spots on the Newborn Metabolic Screening card. Alternative:
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| Test Resources: | Submit requests using the Newborn Metabolic Screening Blood Spot Requisition (card). Please ensure all required information is provided, and "Methionine" is written on the requisition (card). | ||
| Stability and Storage: | Room Temperature | ||
| Processing: | Dry the Newborn Metabolic Screening card for a minimum of 3 hours with protective card flap folded back. Please follow collection instructions on the back of the blood spot card. Ensure "Methionine" is written on the newborn metabolic screening requisition (card). | ||
| Transportation: | Transport at room temperature | ||
| Method and Interpretation of Results: | Methionine and phenylalanine concentrations are measured using flow-injection electrospray-ionization tandem mass spectrometry (FI-MS/MS) with stable-isotope labelled internal standards. Dried blood spot methionine quantitation for homocystinuria screening in asymptomatic infants. | ||
| Routine Turn Around Time: | 4 days | ||
| Testing Schedule: | Daily | ||
| Reference Interval: | Reference intervals will be provided on the report. | ||
| Testing Area: | Newborn Metabolic Screening & Biochemical Genetics | ||
| Performing Site: | University of Alberta Hospital | ||
| Contact Comments: | Newborn Metabolic Screening & Biochemical Genetics North 780-407-8820 | ||
| Last Updated On: | Friday, February 10, 2023 | ||
