Alberta Precision Laboratories

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Organization:

Sub-Page

Test Name/Synonym:

Troponin I High Sensitivity, Triage (Synonym: HS-CTN, HS TNI, hs-cTnI)

Ordering Alert:

Different Troponin assays are not comparable and should NOT be used for trending purposes. Different assays produce different numerical values and use different cutoff.

Collection Alert:

Grossly hemolyzed or clotted samples will be rejected by laboratory staff.

LABID (Connect Care):

LAB139

Specimen Type:

Blood

Primary Container:

LAVENDER EDTA

Alternate Containers:

1 mL whole blood

Specimen Collection Requirements:

Tube should be filled to capacity.

Test Resources:

2-Hour Chest Pain Pathway for Quidel TriageTrue High Sensitivity Troponin-1 Assay

Stability and Storage:

4 hours at room temperature or refrigerated temperature. Do not freeze.

Method:

Quidel Triage® True High Sensitivity Troponin I
WARNING: Different methods give potentially significantly different numerical values. Do not compare results from method to method.

Method and Interpretation of Results:

Hs-TnI Result	Comment
Less than 4 ng/L	For patients with a non-ischemic ECG, a Troponin I, High Sensitivity of 3 ng/L or less on presentation is highly sensitive for excluding acute myocardial infarction, provided the specimen was collected more than 3-hours from symptom onset. However, for patients with symptoms less than 3-hours duration or concerning clinical presentations, repeat troponin testing at 2-hours after the initial sample is recommended. Please note that patients with ischemic ECG changes and/or high-risk clinical presentations should be considered for further evaluation irrespective of troponin results.	Normal
4-20 ng/L	Troponin I, High Sensitivity is below the upper reference limit (21 ng/L) and results are not consistent with myocardial infarction (MI) or injury however, patients with acute symptoms (less than 6-hours) or concerning clinical presentations should undergo repeat troponin testing at 2-hours after the initial sample. Troponin I, High Sensitivity of 4 ng/L or less on presentation AND a 2-hour delta (change) of 2 ng/L or less is highly sensitive for excluding acute myocardial infarction (MI). A 2-hour delta (change) of 3-7 ng/L may indicate acute myocardial injury and suggest an additional troponin measurement 4 hours after the initial sample, serial ECG testing and clinical re-evaluation. A 2-hour delta (change) of 8 ng/L or more suggests an acute myocardial injury and may represent acute myocardial infarction in the appropriate clinical scenario. Please note that patients with ischemic ECG changes and /or high-risk clinical presentations should be considered for further evaluation irrespective of troponin results	Normal
21-59 ng/L	Troponin I, High Sensitivity has a non-specific/non-diagnostic elevation. Interpretation is highly dependent on clinical presentation and patient history. New elevations are concerning; however, many patients have chronic elevations in troponin and measured concentrations near the patient's baseline are reassuring. However, patients with acute symptoms (less than 6-hours) or concerning clinical presentations should undergo repeat troponin testing at 2-hours after the initial sample. A 2-hour delta (change) of 2 ng/L or less is highly sensitive for excluding acute myocardial infarction. A 2-hour delta (change) of 3-7 ng/L may indicate acute myocardial injury and suggest an additional troponin measurement 4 hours after the initial sample, serial ECG testing and clinical re-evaluation. A 2-hour delta (change) of 8 ng/L or more suggests an acute myocardial injury and may represent acute myocardial infarction in the appropriate clinical scenario. Please note that patients with ischemic ECG changes and /or high-risk clinical presentations should be considered for further evaluation irrespective of troponin results	High
Greater than or equal to 60 ng/L	Clear elevation of Troponin I, High Sensitivity consistent with acute myocardial injury or infarction in the appropriate clinical context Repeat troponin testing at 2-hours after the initial sample may be helpful to assess for ongoing myocardial injury.	Critical

Testing Schedule:

Daily

Reference Interval:

Less than 21 ng/L

Critical Value:

Greater than or equal to 60 ng/L

Emergency and inpatient critical Troponin I, High Sensitivity will not be communicated by telephone; only physicians of community patients with a critical value will be contacted.

Testing Area:

Biochemistry

Performing Site:

Central Zone:	Castor – Our Lady of the Rosary Hospital Consort Hospital and Care Centre Coronation Hospital and Care Centre Daysland HC Hanna HC Hardisty HC Killam Health Care Centre Ponoka – CCMHBI Provost HC Sylvan Lake Community HC Tofield HC Two Hills HC Viking HC
North Zone	Boyle Healthcare Centre Elk Point HC Fox Creek Healthcare Centre Grande Cache Community Health Complex Grimshaw/Berwyn and District Community HC Jasper – Seton Healthcare Centre La Crete Community HC Manning Community Healthcare Centre McLennan – Sacred Heart Community Health Care Centre Smoky Lake – George McDougall Healthcare Centre Spirit River – Central Peace Health Complex Wabasca Desmarais Healthcare Centre
South Zone	Bassano HC Bow Island HC Oyen Big Country Hospital Coaldale Health Centre Crowsnest Pass Health Centre Fort Macleod Health Centre Milk River Health Centre

Last Updated On:

Tuesday, June 17, 2025

Registered Trademark Comments:

Quidel Triage® is a trademark of Quidel Cardiovascular Inc.