--- Query Results --- | |||||||
| Organization: | Alberta Precision Laboratories | ||||||
| Message Alert: | PLEASE NOTE: This Test Directory is in an interim state and due to changes pertaining to the DynaLIFE transition, performing site for routing has not been updated. Please refer to Laboratory Information System for appropriate routing. | ||||||
| Test Name/Synonym: | Clozapine Level (Synonym: Clozaril, Desmethylclozapine, Norclozapine) | ||||||
| Ordering Alert: | Record time of last dose on requisition or in electronic ordering system. | ||||||
| Collection Alert: | Collect within 1 hour before next dose or more than 12 hours after last dose. | ||||||
| LABID (Connect Care): | LAB4410 | ||||||
| Specimen Type: | Blood | ||||||
| Primary Container: | RED | ||||||
| Minimum Collection Volume: | 1.0 serum | ||||||
| Test Resources: |
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| Stability and Storage: | Refrigerated – 1 week | ||||||
| Processing: | Centrifuge and aliquot serum. Freeze aliquot if specimen will not be received at performing lab within 1 week. Freeze upon receipt at performing lab. | ||||||
| Transportation: | Calgary Zone:
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| Method: | Calgary: Liquid Chromatography – Mass Spectrometry/Mass Spectrometry Edmonton: Gas Chromatography/Mass Spectrometry | ||||||
| Method and Interpretation of Results: | Routine monitoring of the complete blood cell count is indicated for patients on clozapine therapy to assess toxicity. The correlation between dose and plasma concentration is influenced by age, sex, smoking and pharmacogenetics altered by drug-drug interactions (co-administration). | ||||||
| Testing Schedule: | Weekly | ||||||
| Reference Interval: | Target range: 1070 – 1835 nmol/L | ||||||
| Critical Value: | Clozapine: Greater than 3500 nmol/L Desmethylclozapine (reported by Calgary only): greater than 2000 nmol/L | ||||||
| Testing Area: | TDM/Toxicology | ||||||
| Performing Site: | Calgary: Diagnostic and Scientific Centre Edmonton: University of Alberta Hospital | ||||||
| Additional Test Information: | Steady state: 2-4 days | ||||||
| Last Updated On: | Friday, December 15, 2023 | ||||||
