--- Query Results --- | |||||||
| Organization: | Alberta Precision Laboratories | ||||||
| Message Alert: | PLEASE NOTE: This Test Directory is in an interim state and due to changes pertaining to the DynaLIFE transition, performing site for routing has not been updated. Please refer to Laboratory Information System for appropriate routing. | ||||||
| Test Name/Synonym: | Galactocerebrosidase, T-cell (Synonyms: Galactosylceramidase, GALC, Krabbe, Globoid cell Leukodystrophy, Lysosomal Enzymes Panel) | ||||||
| Clinical Indications: | For the investigation of Krabbe Disease (a.k.a., globoid cell leukodystrophy, galactosylceramidase deficiency, galactocerebrosidase deficiency) - a lysosomal storage disorder. | ||||||
| Ordering Alert: | For those sites that routinely refer tests to Edmonton zone labs, refer to Galactocerebrosidase, Leukocyte
Connect Care Users: Order Lysosomal Enzymes (LAB4043), then select the enzyme(s) to be tested. If ordering through Requisition Entry, order the individual enzyme. This test is considered specialty testing; this test will be cancelled if sufficient clinical justification is not provided. Requests for testing should be supported by a high index of clinical suspicion specific to the disorder in question. | ||||||
| Collection Alert: | Should collection be required at a site other than Alberta Children’s Hospital Outpatient Lab, contact the Biochemical Genetics Lab (403-955-7379) PRIOR TO sample collection for processing and transportation instructions. | ||||||
| Shipping and Handling Alert: | Specimen must be received by a specific time. See Transportation for details. | ||||||
| LABID (Connect Care): | LAB5045 | ||||||
| Test Code: |
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| Specimen Type: | Blood | ||||||
| Primary Container: | Green Top – Sodium Heparin (no gel) | ||||||
| Alternate Containers: | Green Top – Lithium Heparin (no gel) | ||||||
| Minimum Collection Volume: | 3.0 mL whole blood | ||||||
| Specimen Collection Requirements: | Collect one Sodium Heparin (or alternate) tube.
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| Test Resources: | Submit request using the applicable requisition or Connect Care online order entry:
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| Stability and Storage: | Room temperature | ||||||
| Processing: | Do NOT centrifuge. Do NOT aliquot. Do NOT refrigerate or freeze. | ||||||
| Transportation: | Transport whole blood at room temperature.
All specimens MUST arrive in lab by:
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| Method: | Fluorometric | ||||||
| Method and Interpretation of Results: | Galactocerebrosidase activity is measured fluorometrically using a 4-methylumbelliferyl-linked substrate.
This procedure involves the establishment of an IL-2 stimulated T-lymphocyte culture and storage of cell pellets for the purposes of lysosomal enzyme testing. | ||||||
| Routine Turn Around Time: | 45 days | ||||||
| Testing Schedule: | Monthly | ||||||
| Reference Interval: |
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| Testing Area: | Biochemical Genetics | ||||||
| Performing Site: | Alberta Children's Hospial | ||||||
| Additional Test Information: | For priority turn-around contact Biochemical Genetics South Laboratory. | ||||||
| Contact Comments: | Biochemical Genetics 403-955-7379 | ||||||
| Last Updated On: | Monday, September 19, 2022 | ||||||
| Date of Last Review: | Aug 1 2022 12:00AM | ||||||
