Alberta Precision Laboratories

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Organization:

Alberta Precision Laboratories

Message Alert:

PLEASE NOTE: This Test Directory is in an interim state and due to changes pertaining to the DynaLIFE transition, performing site for routing has not been updated. Please refer to Laboratory Information System for appropriate routing.

Test Name/Synonym:

Amiodarone and Metabolite Level (Synonym: Cordarone, Desethylamiodarone)

Ordering Alert:

Note to ordering physician: This test will be reviewed for approval by Laboratory Medical or Clinical Scientific staff.

Record time of last dose on requisition or in electronic ordering system.

Collection Alert:

Collect within 1 hour before next dose.

Best practice is to not draw from an intravenous line through which the drug has been administered as it can produce erroneous results and impact patient care. If best practice is not possible, prior consultation with the most responsible health practitioner is required.

LABID (Connect Care):

LAB567

Test Code:

NORTH ZONE	MISC
SOUTH ZONE	MEDICINE HAT AND AREA: AMINDESA LETHBRIDGE AND AREA: AMI

Specimen Type:

Blood

Primary Container:

RED

Minimum Collection Volume:

1.6 mL whole blood

Specimen Collection Requirements:

Collect 2 RED top tubes
3.0 mL serum preferred

Test Resources:

General Laboratory Requisition – 21302 write test name under “Additional Tests”

Half-life and Time to Steady State

Calgary Zone: Microcollection Minimum Whole Blood Volumes

Calgary Zone: Critical Values

Processing:

Centrifuge and aliquot serum.
All collection sites other than Calgary, Airdrie, Cochrane and Chestermere: freeze serum immediately.

Transportation:

Calgary, Airdrie, Cochrane, and Chestermere collection sites: transport at room temperature.
Other collection sites and other zones: transport frozen.
Diagnostic Scientific Centre: Store frozen after receipt. Ensure frozen specimens do not thaw.

Testing Schedule:

Weekly

Reference Interval:

Desirable Amiodarone target range in patients treated for atrial fibrillation is between 1.1-2.2 µmol/L. Patients with normal metabolism have desethylamiodarone concentrations +/- 20% of the parent drug.

Toxic Levels: The frequency of adverse effects is related to dosage and duration of therapy.

Critical Value:

Greater than 5.4 µmol/L (amiodarone)

Testing Area:

TDM/Toxicology

Performing Site:

Calgary: Diagnostic and Scientific Centre

Additional Test Information:

Steady State: Very long.
A minimum of at least 4 weeks is desirable between dosage changes for checking a level.

Last Updated On:

Tuesday, May 16, 2023