--- Query Results --- | |||
| Organization: | Alberta Precision Laboratories | ||
| Message Alert: | PLEASE NOTE: This Test Directory is in an interim state and due to changes pertaining to the DynaLIFE transition, performing site for routing has not been updated. Please refer to Laboratory Information System for appropriate routing. | ||
| Test Name/Synonym: | Adenosine Deaminase and Purine Nucleoside Phosphorylase and Metabolites, Monitoring (Referred Test) (Synonym: ADA, PNP) | ||
| Clinical Indications: | This test is for the monitoring of known adenosine deaminase (ADA)- or purine nucleoside phosphorylase (PNP)-deficient patients in response to a non-enzyme replacement therapy (non-ERT), such as bone marrow/hematopoietic stem cell transplantation or gene therapy. For the investigation of ADA or PNP deficiency as the cause for an immunodeficiency order Adenosine Deaminase and Purine Nucleoside Phosphorylase (Referred Test). For the purpose of titrating dosing of PEG-ADA ERT in known ADA deficient patients order PEG-Adenosine Deaminase Monitoring (Referred Test) . | ||
| Test Includes: | ADA and PNP enzymatic activities in erythrocytes and levels of associated metabolites. | ||
| Ordering Alert: | The healthcare professional ordering this test must call the Alberta Children’s Hospital (ACH) Biochemical Genetics Laboratory 403-955-7379 or the University of Alberta Hospital (UAH) Biochemical Genetics Laboratory 780-407-8820 at least 24 hours in advance to discuss the reason for referral with the Biochemical Geneticist on-service. Any necessary information pertaining to location and timing of the collection will also be provided. This test is considered specialty testing; this test will be cancelled if sufficient clinical justification is not provided. Pleural or cardiac effusion, sputum or other specimen types for the express purpose of tuberculosis testing will NOT be accepted. | ||
| Collection Alert: | Before collection of specimens, call ACH Biochemical Genetics lab at 403-955-7379 or UAH Biochemical Genetics 780-407-8820. Collect Monday through Wednesday only, excluding holidays. Specimens should be collected early enough in the day to arrive in the ACH or UAH Biochemical Genetics Lab by 12:00 noon on the day of collection. Consult with the lab if other arrangements are necessary. | ||
| Shipping and Handling Alert: | Ship whole blood at room temperature to the ACH or UAH Biochemical Genetics Lab. Specimens must be received in the ACH or UAH Biochemical Genetics Lab on the same day of collection by 12:00 noon, Monday through Wednesday only. For UAH BG Lab: Forward specimens to the UAH External Sendouts team. | ||
| LABID (Connect Care): | LAB50401 | ||
| Specimen Type: | Blood | ||
| Primary Container: | Green Top – NAHEP (no gel) | ||
| Alternate Containers: | Green Top - LIHEP (no gel) or Lavender Top - EDTA | ||
| Minimum Collection Volume: | 2.0 mL whole blood | ||
| Specimen Collection Requirements: | Collect one Sodium heparin (or alternate) tube. | ||
| Test Resources: | Submit request using the applicable requisition or Connect Care online order entry:
Please ensure all required information, including patient's clinical history/indication, is provided on the requisition. | ||
| Stability and Storage: | Room Temperature: 24 hours | ||
| Processing: | Do NOT centrifuge. Do NOT aliquot. Do NOT freeze. | ||
| Transportation: | Transport sample at room temperature. | ||
| Routine Turn Around Time: | 14 days | ||
| Testing Area: | Referred Out | ||
| Performing Site: | Test referred out to Duke University Medical Center | ||
| Last Updated On: | Wednesday, November 8, 2023 | ||
| Date of Last Review: | Aug 1 2022 12:00AM | ||
