--- Query Results ---

  
Program:Genetics and Genomics
 
Test Name:Alpha-Mannosidase (G&G South ACH)
Test Code:A-MAN-P
Performing Site: Alberta Children's Hospital
Performing Dept:Biochemical Genetics
 
Availability:Test is performed on a monthly basis.
TAT:30 days
 
Preferred Tube/Container:Sodium heparin (dark green - NOT PST)
Alternate:Lithium heparin (dark green - NOT PST)
 
Specimen Requirements:Collect 1 x 4.0 mL sodium heparin tube (or alternate tube type).
 
Min. Sample Required:0.25 mL plasma
 
Specimen Processing:At ACH only
The primary heparinized tube can be put on ice (ensure not to freeze sample) or refrigerated for routine pick-ups between 8:30 am – 2:30 pm, Monday through Friday.

For all other collections
1. Centrifuge.
2. Transfer plasma or serum to aliquot tube.
3. Write "NaHep", "LiHep" or "Red Top" on the aliquot tube label.
4. Freeze.
 
Specimen Handling:Transport frozen samples on ice. Samples must not thaw during transport.
 
Additional Information:It is recommended that patients go to ACH OP Lab for specimen collection.
If multiple lysosomal enzymes are requested on plasma, a minimum of 0.25 mL plasma is required for each enzyme requested.

Samples will be rejected if:
  • Primary tube not refrigerated
  • Aliquot tube received thawed
  • Tube type not written on aliquot tube label
  • Serum is submitted
  •  
    Requisition/Form:Submit request using Biochemical Genetics Laboratory Requisition.
    Please ensure all required information, including patient's clinical history/indication, is provided on the requisition.
     
    Order Restrictions:This test is considered specialty testing; this test will be cancelled if sufficient clinical justification is not provided.

    Requests for testing should be supported by a high index of clinical suspicion specific to the disorder in question, and/or by the results of an abnormal Oligosaccharides Screen, Urine (UAH: OLIGO) and evidence from additional send-out testing
     
    Indications:For the investigation of alpha-Mannosidosis (a.k.a., alpha-mannosidase deficiency) - a lysosomal storage disorder.
    Method:Alpha-mannosidase activity is measured fluorometrically using a 4-methylumbelliferyl-linked substrate.
    Reference Interval:
    alpha-Mannosidase    0.14 – 1.08   nmol/min/ml plasma
     
    Comments:Contact ACH Biochemical Genetics Laboratory (403-955-7379) for priority turn-around.
     
     
    Last Updated On:Monday, March 26, 2018
    Date of Last Review:Jan 2 2018 12:00AM