--- Query Results ---

  
Program:Genetics and Genomics
 
Test Name:Allopurinol Loading Test (G&G South ACH)
Test Code:OR/OD
Performing Site: Alberta Children's Hospital
Performing Dept:Biochemical Genetics
 
Availability:ARRANGED - prior arrangement is required before ordering - see additional test information.
TAT:14 days
 
Preferred Tube/Container:Random urine collection container AND four 24 hour urine collection containers (no preservative)
 
Specimen Requirements:PRE Allopurinol Load
1. Collect 5 - 10 mL random urine sample.

POST Allopurinol Load
1. Label the first 24-hour collection container with the start time and collect the total urine output for the next
    six hours into the container.
2. Label the second 24-hour collection container with the start time and collect the total urine output for the
    next six hours into the container.
3. Label the third 24-hour collection container with the start time and collect the total urine output for the next
    six hours into the container.
4. Label the forth 24-hour collection container with the start time and collect the total urine output for the next
     six hours into the container.
 
Min. Sample Required:N/A
 
Specimen Processing:1. Freeze initial pre-load urine sample as well as each 6 hour interval total urine output collections in the primary
    collection containers. DO NOT aliquot any sample.
2. Urine specimen MUST be kept FROZEN during the entire collection and transport process.
 
Specimen Handling:Do NOT thaw samples.
Transport the pre-load random urine sample and the 4 x 6hr post-load total urine sample collections frozen in the primary collection containers.
 
Additional Information:Samples will be rejected if:
  • Specimens received thawed
  • Specimens not received in primary collection containers
  •  
    Requisition/Form:Submit request using Biochemical Genetics Laboratory Requisition.
    Please ensure all required information, including patient's clinical history/indication, is provided on the requisition.
     
    Order Restrictions:This test is considered specialty testing; this test will be cancelled if sufficient clinical justification is not provided.
     
    Indications:For the determination of ornithine transcarbamylase heterozygote status in a female patient suspected based on clinical findings, or partial ornithine transcarbamoylase deficient males who have had normal or borderline urinary orotic acid levels under normal conditions and/or normal molecular genetic testing.
    Method:Orotic acid and orotidine are detected using liquid chromatography, electrospray-ionization tandem mass spectrometry (LS-MS/MS) with deuterium-labelled internal standards.
    Method Details:Metabolites reported:
  • orotic acid
  • orotidine
  •  
    Comments:Contact ACH Biochemical Genetics Laboratory (403-955-7379) for priority turn-around.
     
     
    Last Updated On:Monday, October 30, 2017
    Date of Last Review:Jan 2 2018 12:00AM