--- Query Results ---

  
Program:Genetics and Genomics
 
Test Name:Glycosaminoglycan (Mucopolysaccaride) Screen (G&G South ACH)
Test Code:MPSSCREEN
Performing Site: Alberta Children's Hospital
Performing Dept:Biochemical Genetics
 
Availability:Test performed on a weekly basis.
TAT:8 days
 
Preferred Tube/Container:Random specimen: plain urine container
 
Specimen Requirements:1.  Prefer first morning void.
2.  Collect 5-10 mL random urine sample.
 
Min. Sample Required:4.0 mL urine.
 
Specimen Processing:1.  If specimen is transferred to secondary aliquot tube or container, write "urine" on label.
2.  Freeze.
 
Specimen Handling:Transport frozen samples on ice. Samples must not thaw during transport.
 
Additional Information:Samples will be rejected if:
  • Primary container or aliquot tube received thawed
  • Sample type not written on aliquot tube label
  •  
    Requisition/Form:Submit request using Biochemical Genetics Laboratory Requisition.
    Please ensure all required information, including patient's clinical history/indication, is provided on the requisition.
     
    Order Restrictions:None
     
    Indications:This screen is a simple and rapid method for the initial investigation for mucopolysaccharidoses (a.k.a., disorders of glycosaminoglycan catabolism). This test should not be used to monitor known mucopolysaccharidosis patients on treatment as this is a qualitative test.
    Method:Increased urinary mucopolysaccharides are detected using both toluidine blue spot and cetyltrimethylammonium-bromide (CTMAB) turbidity tests. Positive and negative controls are run with patient samples.
    Method Details:Positive toluidine blue and CTMAB tests indicating the presence of increased urine mucopolysaccharides (a.k.a., glycosaminoglycans or GAGs) will result in reflexive quantitative uronic acids and GAG electrophoresis testing on the same sample, volume permitting.
     
    Reference Interval:N/A
     
    Comments:Contact ACH Biochemical Genetics Laboratory (403-955-7379) for priority turn-around.
     
     
    Last Updated On:Tuesday, May 22, 2018
    Date of Last Review:Jan 2 2018 12:00AM