--- Query Results ---

Program:Genetics and Genomics
Test Name:Glycosaminoglycan Electrophoresis, Qualitative (G&G South ACH)
Test Code:GAG
Performing Site: Alberta Children's Hospital
Performing Dept:Biochemical Genetics
Availability:Test is performed on a monthly basis.
TAT:45 days
Preferred Tube/Container:Random specimen: plain urine container
Specimen Requirements:1.  Prefer first morning void.
2.  Collect 5-10 mL random urine sample.
Min. Sample Required:4.0 mL urine
Specimen Processing:1.  If specimen is transferred to secondary aliquot tube or container, write "urine" on label.
2.  Freeze.
Specimen Handling:Transport frozen samples on ice. Samples must not thaw during transport.
Additional Information:Samples will be rejected if:
  • Primary container or aliquot tube received thawed
  • Sample type not written on aliquot tube label
    Requisition/Form:Submit request using Biochemical Genetics Laboratory Requisition.
    Please ensure all required information, including patient's clinical history/indication, is provided on the requisition.
    Order Restrictions:This test is considered specialty testing; this test will be cancelled if sufficient clinical justification is not provided.

    This test is for the investigation of mucopolysaccharidoses and is required to be performed in conjunction with Uronic Acids, Quantitative (ACH). Minimum volume is for both tests.
    Indications:This test should be ordered (in conjunction with quantitative uronic acids) when there is a strong clinical suspicion of a mucopolysaccharidosis in a patient, or when the initial glycosaminoglycan (mucopolysaccharide) screen has been found to be abnormal and there was insufficient sample for reflexive testing.
    Method:Discontinuous one-dimensional cellulose acetate electrophoresis.
    Method Details:The presence of abnormal glycosaminoglycans dermatan and/or heparan sufate, or keratan sulfate, in addition to the normal urine constituents chondroitin 4 and 6 sulfates, is highly suggestive of a biochemical diagnosis of a mucopolysaccharidosis. Such a finding should be supported by an elevated quantitative uronic acid level in the majority of cases. Further enzyme or molecular-based testing is required to confirm the specific enzyme deficiency in each case.
    Reference Interval:N/A
    Comments:Contact ACH Biochemical Genetics Laboratory (403-955-7379) for priority turn-around.
    Last Updated On:Thursday, August 31, 2017
    Date of Last Review:Jan 2 2018 12:00AM